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Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations

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Journal Title: 
Pediatric Blood & Cancer
Primary Author: 
Shimano KA
Author(s): 
Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, Boklan J
Original Publication Date: 
Thursday, May 16, 2024
Full Article on PubMed: 
https://www.ncbi.nlm.nih.gov/pubmed/38757488/
Bone Marrow Disease(s): 

Severe aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials. Because of the rarity of the disease, some pediatric hematologists may have relatively limited experience with the complex management of SAA. The following recommendations reflect an up-to-date evidence-based approach to the treatment of children with newly diagnosed SAA.